Folate (categories)
Folate range (<45.3 vs >=45.3)
Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
PRL (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
130.8498286
|
1
|
<0.0001
|
***
|
|
Folate_gp
|
1.5474194
|
1
|
0.2
|
ns
|
|
Study
|
0.0028985
|
1
|
1.0
|
ns
|
|
GA_samp
|
129.9037148
|
1
|
<0.0001
|
***
|
|
Folate_gp:Study
|
0.1873616
|
1
|
0.7
|
ns
|
hPL (μg/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
31.8026411
|
1
|
<0.0001
|
***
|
|
Folate_gp
|
0.5247425
|
1
|
0.5
|
ns
|
|
Study
|
15.3487117
|
1
|
<0.0001
|
***
|
|
GA_samp
|
1637.3958932
|
1
|
<0.0001
|
***
|
|
Folate_gp:Study
|
1.3445950
|
1
|
0.2
|
ns
|
GH2 (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
340.5884144
|
1
|
<0.0001
|
***
|
|
Folate_gp
|
0.8284085
|
1
|
0.4
|
ns
|
|
Study
|
0.9187959
|
1
|
0.3
|
ns
|
|
GA_samp
|
809.0684784
|
1
|
<0.0001
|
***
|
|
Folate_gp:Study
|
1.6021790
|
1
|
0.2
|
ns
|
Insulin (uU/ml)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp
|
1
|
Inf
|
4.454
|
4.454
|
0.03
|
*
|
|
3
|
Study
|
1
|
Inf
|
10.576
|
10.576
|
0.001
|
**
|
|
4
|
GA_samp
|
1
|
Inf
|
0.113
|
0.113
|
0.7
|
ns
|
|
2
|
Folate_gp:Study
|
1
|
Inf
|
0.585
|
0.585
|
0.4
|
ns
|
HOMA-IR
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp
|
1
|
Inf
|
3.940
|
3.940
|
0.05
|
ns
|
|
3
|
Study
|
1
|
Inf
|
20.069
|
20.069
|
<0.0001
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.199
|
0.199
|
0.7
|
ns
|
|
2
|
Folate_gp:Study
|
1
|
Inf
|
0.723
|
0.723
|
0.4
|
ns
|
Glucose (mmol/L)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
Folate_gp
|
1
|
Inf
|
0.361
|
0.361
|
0.5
|
ns
|
|
3
|
Study
|
1
|
Inf
|
53.217
|
53.217
|
<0.0001
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.198
|
0.198
|
0.7
|
ns
|
|
2
|
Folate_gp:Study
|
1
|
Inf
|
1.123
|
1.123
|
0.3
|
ns
|
Model summary
Ratio of Geometric means (95% CI)
PRL (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
12.92 (8.33, 20.02)
|
<0.0001
|
|
Folate_gp≥45.3
|
0.93 (0.86, 1.02)
|
0.14
|
|
StudySTOP
|
1.01 (0.88, 1.16)
|
0.86
|
|
GA_samp
|
1.17 (1.14, 1.20)
|
<0.0001
|
hPL (μg/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.92 (1.54, 2.41)
|
<0.0001
|
|
Folate_gp≥45.3
|
0.99 (0.95, 1.04)
|
0.75
|
|
StudySTOP
|
1.14 (1.07, 1.23)
|
0.0002
|
|
GA_samp
|
1.34 (1.32, 1.36)
|
<0.0001
|
GH2 (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
0.06 (0.05, 0.08)
|
<0.0001
|
|
Folate_gp≥45.3
|
0.99 (0.93, 1.06)
|
0.87
|
|
StudySTOP
|
1.03 (0.94, 1.13)
|
0.53
|
|
GA_samp
|
1.32 (1.29, 1.34)
|
<0.0001
|
Insulin (uU/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
16.05 (9.08, 28.36)
|
<0.0001
|
|
Folate_gp≥45.3
|
0.88 (0.79, 0.99)
|
0.04
|
|
StudySTOP
|
0.71 (0.60, 0.86)
|
0.0003
|
|
GA_samp
|
0.99 (0.96, 1.03)
|
0.74
|
HOMA-IR
|
Var
|
Effect
|
P
|
|
(Intercept)
|
4.00 (2.21, 7.25)
|
<0.0001
|
|
Folate_gp≥45.3
|
0.89 (0.78, 1.00)
|
0.06
|
|
StudySTOP
|
0.62 (0.51, 0.75)
|
<0.0001
|
|
GA_samp
|
0.99 (0.95, 1.03)
|
0.66
|
Glucose (mmol/L)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
5.53 (4.97, 6.16)
|
<0.0001
|
|
Folate_gp≥45.3
|
1.01 (0.98, 1.04)
|
0.42
|
|
StudySTOP
|
0.87 (0.84, 0.90)
|
<0.0001
|
|
GA_samp
|
1.00 (0.99, 1.01)
|
0.63
|
Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
PRL (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
94.28120
|
7.881276
|
105.81912
|
79.88169
|
111.2764
|
|
STOP
|
95.46369
|
7.493420
|
82.64525
|
81.66396
|
111.5953
|
hPL (μg/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
89.55766
|
2.703633
|
200.0909
|
84.38197
|
95.0508
|
|
STOP
|
102.42476
|
2.760721
|
126.5065
|
97.10473
|
108.0363
|
GH2 (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
2.270358
|
0.0783020
|
457.2962
|
2.121580
|
2.429569
|
|
STOP
|
2.339495
|
0.0664836
|
239.7681
|
2.212127
|
2.474197
|
Insulin (uU/ml)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
13.92731
|
0.8952145
|
Inf
|
12.278749
|
15.79722
|
|
STOP
|
9.94880
|
0.4661921
|
Inf
|
9.075784
|
10.90579
|
HOMA-IR
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
3.367075
|
0.2289763
|
Inf
|
2.946912
|
3.847143
|
|
STOP
|
2.078715
|
0.1024898
|
Inf
|
1.887239
|
2.289617
|
Glucose (mmol/L)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
5.441858
|
0.0705402
|
Inf
|
5.305343
|
5.581886
|
|
STOP
|
4.733070
|
0.0429425
|
Inf
|
4.649648
|
4.817988
|
Comparisons (Overall)
|
Hormone
|
Contrast
|
Ratio of Geometric means (95% CI)
|
P-value
|
|
PRL (ng/ml)
|
≥45.3 / <45.3
|
0.93 (0.86, 1.02)
|
0.1
|
|
hPL (μg/ml)
|
≥45.3 / <45.3
|
0.99 (0.95, 1.04)
|
0.8
|
|
GH2 (ng/ml)
|
≥45.3 / <45.3
|
0.99 (0.93, 1.06)
|
0.9
|
|
Insulin (uU/ml)
|
≥45.3 / <45.3
|
0.88 (0.79, 0.99)
|
0.04
|
|
HOMA-IR
|
≥45.3 / <45.3
|
0.89 (0.78, 1.00)
|
0.06
|
|
Glucose (mmol/L)
|
≥45.3 / <45.3
|
1.01 (0.98, 1.04)
|
0.4
|
Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)

Diagnositcs for hPL (μg/ml)

Diagnositcs for GH2 (ng/ml)

Diagnositcs for Insulin (uU/ml)

Diagnositcs for HOMA-IR

Diagnositcs for Glucose (mmol/L)
